PHARMA KING ACE

  LIST OF CRITICAL PARAMETERS DURING GRANULATION During the process of granulation in tablet manufacturing a number of parameters to be considered here some of them listed    1.       Cleaning of area prior to granulation    2.       Maintain environmental conditions    3.       Absence of foreign particles    4.       Types of binder    5.       Types of binding (impeller & chopper speed and timing)    6.       Temperature of drying    7.       Time of drying    8.       Loss on drying    9.       Final granule size    10.   % compressibility    11.   Flow of powder    12.   Ratio of gran...

Definition of Tablets Tablets can be defined as Solid Pharmaceutical Dosage form containing drug substances with or without suitable  diluent  and prepare either by compression or  moulding  methods. Tablet Tooling For this purpose different types of punches are used: Flat- faced bevel- edged. Shallow concave (Round/ Capsule shaped) Standard concave (Round/ Capsule shaped) Deep concave (Round/ Capsule shaped) Extra deep. Modified ball The basic mechanical unit in all tablet-compression equipment includes a lower punch which fits into a die from the bottom and an upper punch, having a head of the same shape and dimensions, which enters the die cavity from the top after tablet material fills the die cavity. PROCUREMENT OF  TOOLING While ordering any punch set ( From Approved Supplier only ), following things should be covered: Drawing for upper/lower punch / die, by the manufacturer as per the specifications given or as per samp...

A titration (titrimetry) is a technique where a solution of known concentration is used to determine the concentration of an unknown solution. Typically, the titrant (the know solution) is added from a buret   to a known quantity of the analyte (the unknown solution) until the reaction is complete. Knowing the volume of titrant added allows the determination of the concentration of the unknown. Often, an indicator is used to usually signal the end of the reaction, the endpoint. Titrations can be classified by the type of reaction. Different types of titration reaction include: Acid-base titrations are based on the neutralization reaction between the analyte and an acidic or basic titrant. These most commonly use a pH indicator, a pH meter, or a conductance meter to determine the endpoint. Redox titrations are based on an oxidation-reduction reaction between the analyte and titrant. These most commonly use a potentiometer or a redox indicator t...

Disintegration test for Enteric coated tablets The Enteric coated tablets are those tablets which bypass the stomach and get metabolize in the intestine. So firstly the disintegration test done with 0.1 M HCL for 2 hours, tablets should not dissolve in it till 2 hours without disc . Then it must dissolve completely in phosphate buffer solution of 6.8 pH in 1 hour with or without disc. Preparation of 0.1 M HCL- Add 8.5 ml of concentrated HCL (37.5%) in 100 ml of water in a volumetric flask with continuously stirring and then make up the volume to 1000 ml with water and stir well. Preparation of Phosphate buffer solution 6.8pH- 1.        Mixed Phosphate Buffer pH 6.8 As Per IP :- 28.80 gm of disodium hydrogen phosphate and 11.45 gm of Potassium dihydrogen phosphate in 1000 ml with water. 2.        Add 6.8 gm KH2PO4 and about 0.94 gm NaOH in 1000mL Water. Adjust the pH of solution by using dilute Orthophosphoric ...

Walk in for Ind swift laboratories ltd Chandigarh at 30 July 2017 and 31 July 2017 for both fresher and experienced candidates at multiple vacancies 

Fluidized bed dryers, their construction, working, FBD finger bags, finger bag MOC and their features and application in pharmaceutical manufacturing. Drying in pharmaceutical manufacturing   is the removal of water and other liquid solvents from the granules or other materials by heat and a current of air. Fluidized bed dryer is used to dry the granules in pharmaceuticals using FBD finger bags. Principle of Fluidized Bed Dryer (FBD): 1. In fluidized bed dryer hot air is passed at high pressure through a perforated bottom of the container containing granules to be dried. 2. The granules are lifted from the bottom and suspended in the stream of air this condition is called fluidized state. 3. The hot air is surrounding every granule and dries them completely. Therefore, the granules dry equally. Construction: The dryer is generally made up of stainless steel. A removable bowl is attached at the base of the dryer that is used for loading and unloading o...