PHARMA KING ACE

Tablet tooling: Don’t let it corroded Corrosion can severely affect tablet compression tooling if it is not addressed effectively. It can delay production, reduce efficiency and cause contamination problems. Corrosion can be detected by the appearance of discoloration, etching or common red rust. The main cause of corrosion is acidic substances, which can include ingredients found within the formulation being compressed and even in the surrounding atmosphere. The iron particles in the metal tooling are exposed to oxygen and moisture in the form of humidity or vapor. When the steel is exposed to water, the iron particles are lost to the water’s acidic electrolytes. This means they oxidize the iron particles, which form corrosion on the punches and dies. There are several reasons why corrosion can occur, and although challenging, it can be resolved with a combination of the correct steel, coating or treatment selection and proper maintenance procedures. Atmospheric moisture One of the pr...

 Following parameters checked during granulation process  1. Angle of repose-  Angle of repose of any solid in pulverized form represent an angle measured in theta,  Angle of repose = tan-¹(2h/d), unit is degree (°) Acceptance =  < 25° = Excellent  25°-30°= Good 30°-40°= Average  >40°= Bad  2. LOD ( Loss on Drying )  Test is designed to measure the amount of water and volatile matters in a sample when the sample is dried under specified conditions eg. 100° C for 5 minutes  Formula  LOD = Initial weight before drying - final weight after drying / initial weight before drying ×100 3. Compressibility index  Measure of the propensity of a powder to be Compressed also known as Carr's index  Formula  Carr's index = true density - bulk density / bulk density ×100 Acceptance  <15% = Good flow  >25% = Poor flow  15%- 25% = Smooth for compression  4. Bulk density and tap density  Bulk densit...