PHARMA KING ACE

 In pharmaceutical manufacturing, particularly in the **Rapid Mixer Granulator (RMG)**, several **Critical Process Parameters (CPPs)** must be closely controlled to ensure the granulation process is consistent, reproducible, and results in a high-quality product. These parameters directly influence the granule properties such as size, density, and uniformity, which in turn affect the drug's dissolution, bioavailability, and stability. ### Key Critical Process Parameters (CPPs) in RMG: 1. **Impeller Speed (Mixing Speed)**:    - **Impact**: The impeller speed determines the shear and intensity of the mixing action. Too low a speed may lead to inadequate mixing, while too high can result in excessive shearing and over-granulation, which can cause poor flowability and excessive fines.    - **Control**: Typically adjusted based on the formulation requirements, with optimal speeds being set for different stages of granulation. 2. **Chopper Speed**:    - **Im...