Following parameters checked during granulation process
1. Angle of repose-
Angle of repose of any solid in pulverized form represent an angle measured in theta,
Angle of repose = tan-¹(2h/d), unit is degree (°)
Acceptance =
< 25° = Excellent
25°-30°= Good
30°-40°= Average
>40°= Bad
2. LOD ( Loss on Drying )
Test is designed to measure the amount of water and volatile matters in a sample when the sample is dried under specified conditions eg. 100° C for 5 minutes
Formula
LOD = Initial weight before drying - final weight after drying / initial weight before drying ×100
3. Compressibility index
Measure of the propensity of a powder to be Compressed also known as Carr's index
Formula
Carr's index = true density - bulk density / bulk density ×100
Acceptance
<15% = Good flow
>25% = Poor flow
15%- 25% = Smooth for compression
4. Bulk density and tap density
Bulk density = density of powder in ML ( gm per ml )
Tap density = density of powder in ML after tapping at specified power in specified time.
Instrument used - sieve Shaker ( 20#, 40# ,60#)
eg.
Blend weight = 50gm
Initial vol. of blend = 74ml
After 500 tap blend = 64ml
After 750 tap blend = 64ml
BD =
50/74= 0.68%
TD=
50/64= 0.78%
