PHARMA KING ACE

Vacancy at zee Laborate limited

TYPES OF GRANULATION Granulation can be achieved by three method as follows :- 1. Direct compression          Crystalline substance like sodium chloride, sodium bromide may be compressed directly. The vast majority of medicinal agents are rarely so easy to tablet, direct compression material should posses good flow and compresibility and must be inert, tasteless, able to disintegrate and inexpensive. Method (Drug + filler + disintegrant + lubricant + glidant ) all are blend directly after sifting through Viber sifter and compressed 2. Dry Granulation    It is used in situations where effective dose of a drug is too high for direct compaction and the drug is sensitive to heat, moisture, or both which preclude wet granulation. This is also called slugging method. Method A.      (Drug + filler + lubricant) All are.       blend then precompression done and     after that   comminu...

THIN LAYER CHROMATOGRAPHY Introduction Thin layer chromatography (TLC) is a technique in which a solute undergoes distribution between two phases, a stationary phase, acting through adsorption and a mobile phase in the form of liquid. The adsorbent is relatively thin, uniform layer of dry, finely powdered material applied to glass, plastic or metal sheet. Glass plates are most commonly used. Separation may also be achieved on the basis of partition or a combination of partition and adsorption, depending on a particular type of support, its preparation and its use with different solvent. Identification can be effected by observation of spots of identical Rf value and about equal magnitude obtained respectively, with an unknown and reference sample chromatograph on the same plate. Apparatus required Flat  glass plates of appropriate dimensions. b)  An aligning tray or plate surface on which the plates can be aligned and        ...

POLARIMETRY Introduction The electric fields associated with the beam of monochromatic light, vibrate in all directions perpendicular to the directions of propagation of light. Certain crystalline materials have different refractive indices for light, whose field vibrates parallel or perpendicular to the principal plane of the crystal. As a result, a Nicol prism constructed of this material transmits only light whose electric field oscillates in one plane. Optical activity concerns with the interaction of such plane polarised light with certain materials, particularly solutions of some organic compounds. When a plane polarised light passes through a medium, it is retarded to an extent indicated by the refractive index of the medium. When the later is optically inactive, both circularly polarised components are retarded to the same extent and the beam emerges from the medium, polarised in the same plane as the incident beam. If the medium is optically active, the components are re...