PHARMA KING ACE

 Following parameters checked during granulation process  1. Angle of repose-  Angle of repose of any solid in pulverized form represent an angle measured in theta,  Angle of repose = tan-¹(2h/d), unit is degree (°) Acceptance =  < 25° = Excellent  25°-30°= Good 30°-40°= Average  >40°= Bad  2. LOD ( Loss on Drying )  Test is designed to measure the amount of water and volatile matters in a sample when the sample is dried under specified conditions eg. 100° C for 5 minutes  Formula  LOD = Initial weight before drying - final weight after drying / initial weight before drying ×100 3. Compressibility index  Measure of the propensity of a powder to be Compressed also known as Carr's index  Formula  Carr's index = true density - bulk density / bulk density ×100 Acceptance  <15% = Good flow  >25% = Poor flow  15%- 25% = Smooth for compression  4. Bulk density and tap density  Bulk densit...

  MONTHLY CALIBRATION OF BALANCES  For monthly Calibration of Balances check following parameters- 1. Accuracy - verify the balance with minimum weight (least count × 100), 5%, 20%, 50%, 90% capacity of respective balance capacity. Tolerance - the variation if any should be ± least count of the balance or ± 0.2% of certified standard weight used whichever is higher    2. Reproducibility -  Check the reproducibility by using minimum standard weight of balance capacity. Place the weight in the middle of the weighing pan observe the displayed value  Then calculate the %RSD by following formula  RSD= SD×100 / X  Where,  X= mean of the individual value Acceptance = %RSD should not be more than 2.0% 3. Eccentricity  Eccentricity is the difference between the weight placed in centre and at peripheral points of the weighing pan